Terbinafine belongs to allylamine class of antifungal drugs. It works by weakening the fungal cell membrane. It mainly indicated for the treatment of nail and nail infections. It has longer duration of action and distributes in the cells. It also reduces the risk of liver disorders. Indication⇛ Candidiasis⇛ Onychomycosis ⇛ Tinea capitis ⇛ Tinea pedis ⇛ Sporotrichosis PharmacologyMechanism of Action:Terbinafine inhibits the squalene epoxidase thus prevents the formation of ergosterol which results in accumulation of the squalene which further leads to weakening of the fungal cell wall.Pharmacokinetics:Absorption: It is absorbed orallyProtein Binding: It is 99% bound to proteins Metabolism: It undergoes hydroxylation and N-demethylation Excretion: It is excreted via urine Side Effects⇛ Headache⇛ Rashes ⇛ Diarrhoea ⇛ Stomach upset ⇛ Itching ⇛ Nausea ⇛ Change in taste Contraindication⇛ Contraindicated in liver disease⇛ Contraindicated in people with allergic to it Drug Interaction⇛ Fluconazole⇛ Ketoconazole ⇛ Cimetidine ⇛ Amiodarone Disclaimer:The data uploaded is made from content already available on internet.The company holds no right of it and is not responsible for any wrong information. |
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